Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2006-04-18
2006-04-18
Nolan, Patrick J. (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S146100, C435S006120
Reexamination Certificate
active
07029675
ABSTRACT:
A method for treating or preventing infarction of a patient comprising administering a hepsin antagonist with a dosage effective to suppress or inactivate hepsin's expression over a sustained period.
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patent: WO 97/47651 (1997-12-01), None
Rutsch et al. Herz, Dec. 1994: 19(6): 336-352, German Document, Abstract only.
Torres-Rosado A., et al., “Hepsin, a Putative Cell-Surface Serine Protease, is Required for Mammalian Cell Growth” Proc. Natl. Acad. Sci. USA vol. 90, pp. 7181-7185, Aug. 1993.
Kazama Y. et al., “Hepsin, a Putative Membrane-Associated Serine Protease, Activates Human Factor VI and Initiates a Pathway of Blood Coagulation on the Cell Surface Leading to Thrombin Formation” The Journal of Biological Chemistry, vol. 270, No. 1, pp. 66-72, 1995.
Zacharski L.P. et al, “Expression of the Factor VII Activating Protease, Hepsin, In Situ in Renal Cell Carcinoma” Thromb Haemost 1998; 79: 876-877.
Dissmann R. et al., “Estimation of Enzymatic Infarct Size: Direct Comparison of the Marker Enzymes Creatine Kinase and -Hydroxybutyrate Dehydrogenase” Am Heart J 135(1):1-9, 1998.
Product Brochure “100022 Hepsin Polyclonal Antibody Affinity-Purified (AA 241-260)” Cayman Chemical Company 2003.
Product Brochure “100024 Hepsin Blocking Peptide (AA 241-260)” Cayman Chemical Company 2003.
Chu Pao-Hsien
Lin Shu-Wha
Lin Teng-Nan
Tu Hosheng
Yu I-Shing
Kim Yunsoo
Nolan Patrick J.
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