Hepp, a novel gene with a role in hematopoietic and neural...

Details Hepp, a novel gene with a role in hematopoietic and neural... Hepp, a novel gene with a role in hematopoietic and neural...

2005-03-29

2005-03-29

Woitad, Joseph (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C800S018000

Reexamination Certificate

active

06872812

ABSTRACT:
The invention is directed to an isolated gene and protein product, designated Hepp, which has a role in mammalian hematopoiesis and neural function, and is further directed to a genetically modified non-human mammal that is homozygous or heterozygous for a disruption in the endogenous Hepp gene.

REFERENCES:
Isomura, Genbank Accession AP000070, first published Apr. 8, 1999.*
Ngo, in The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 and 492-495, 1994.*
Rudinger in Peptide Hormones, Persons (ed.), University Park Press: Baltimore, MD, pp. 1-7, 1976.*
Akaboshi, 2003, Human Mutation, vol. 22, pp. 442-450.*
Sequence alignment SEQ ID NO:1 with Kargul, Jan. 2001, Genbank Accession No. BG069072.*
Sequence alignment SEQ ID NO:1 with Kargul, Jan. 2001, Genbank Accession No. BG082096.*
Arakawa, Jun. 2000, Genbank Accession No. BB055758.*
Yahyawi, Dec. 2000, Genbank Accession No. BF607870.*
Sequence alignment SEQ IQ NO:1 with Gallatin, 1998, USPN 5,831,029, SEQ ID NO: 45.*
James M. Abdullah, et al., “Cloning and Characterization of hepp, a Novel Gene Expressed Preferentially in Hematopoietic Progenitors and Mature Blood Cells”, Blood Cells, Molecules and Diseases, 27(3), May/Jun. 2001, pp. 667-676.
GenBank Data Entry, Access No. AF322238 (Jul. 5, 2001).
GenBank Data Entry, Access No. AF 322239 (Jul. 5, 2001).
GenBank Data Entry, Access No. AK000771 (Feb. 22, 2000).

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