Hepatoma specific chimeric regulatory sequence

Details Hepatoma specific chimeric regulatory sequence Hepatoma specific chimeric regulatory sequence

2007-01-02

2007-01-02

Qian, Celine (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C435S320100

Reexamination Certificate

active

11030110

ABSTRACT:
The present invention relates to a chimeric regulatory sequence with hepatoma cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer of 5′ flanking region of human α-fetoprotein (AFP) gene.

REFERENCES:
patent: 5804407 (1998-09-01), Tamaoki et al.
patent: 6254862 (2001-07-01), Little et al.
patent: 2003/0017139 (2003-01-01), Souza et al.
patent: 2134994 (1995-05-01), None
Su et al. Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther. vol. 7, No. 4, pp. 463-470, Mar. 1996.
Yoshitake Hayashi, Jeannie Chan, Hidekazu Nakabayashi, Tomoko Hasimoto, and Taiki Tamaoki, “Identification and Characterization of Two Enhancers of the Human Albumin Gene”, The Journal of Biological Chemistry, vol. 267, No. 21, issue of Jul. 25, 1992, pp. 14580-14585.
Kazutada Watanabe, Akira Saito and Taiki Tamaoki, “Cell-specific Enhancer Activity in a Far Upstream Region of the Human α-Fetoprotein Gene”, The Journal of Biological Chemistry, vol. 262, No. 10, issue of Apr. 5, 1987, pp. 4812-4818.

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