Hepatocyte-targeting vehicle for delivery of glargine...

Details Hepatocyte-targeting vehicle for delivery of glargine... Hepatocyte-targeting vehicle for delivery of glargine...

2011-01-18

2011-01-18

Landsman, Robert (Department: 1646)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S078080, C424S200100

Reexamination Certificate

active

07871641

ABSTRACT:
The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free glargine insulin and glargine insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Glargine insulin is present within the complex in at least one form wherein the glargine insulin has a positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.

REFERENCES:
patent: 4603044 (1986-07-01), Geho et al.
patent: 4963526 (1990-10-01), Ecanow
patent: WO 88/00474 (1988-01-01), None
patent: WO 99/59545 (A1) (1999-11-01), None
Heinemann et al., Diabetes Care 23: 644-649, 2000.

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