Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1992-05-18
1994-07-12
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
530399, 536 2351, C12P 2106, A61K 3736
Patent
active
053288378
ABSTRACT:
The invention concerns hepatocyte growth factor (HGF) variants that compise an amino acid alteration at a site within the protease domain of HGF and retaining substantially full receptor binding affinity of the corresponding wild-type HGF.
REFERENCES:
patent: 4330528 (1982-05-01), Ruhenstroth-Bauer et al.
patent: 4341765 (1982-07-01), Ruhenstroth-Bauer et al.
patent: 5004805 (1991-04-01), Gohda et al.
Matsumoto et al, 1991 Biochem. Biophys. Res. Commun. 181(2):691-699.
Gak, et al., "Processing of Hepatocyte Growth Factor to the Heterodimeric Form is Required for Biological Activity," FEBS Letters 311(1): 17-21 (1992).
Lokker, N. et al., "Structure-Function Analysis of Hepatocyte Growth Factor: Identification of Variants that Lack Mitogenic Activity Yet Retain High Affinity Receptor Binding," EMBO J. 11(7): 2503-2510 (1992).
Naka, D. et al., "Activation of Hepatocyte Growth Factor by Proteolytic Conversion of a Single Chain Form to a Heterodimer," J. Biol. Chem. 267(88): 20114-20119 (1992).
Seki, T. et al., "Isolation and Expression of cDNA for Different Forms of Hepatocyte Growth Factor from Human Leukocyte," Biochem. Biophys. Res. Comm. 172(1): 321-327 (1990).
Shima, N. et al., "Tumor Cytotoxic Factor/Hepatocyte Growth Factor from Human Fibroblasts: Cloning of Its cDNA, Purification and Characterization of Recombinant Protein," Biochem. Biophys. Res. Com. 180(2): 1151-1158 (1991).
Asami et al., J. Biochem. 109, 8-13 (1991).
Bottaro et al., Science 251, 802-804 (1991).
Chan et al., Science 254, 1382-1385 (1991).
Cooper et al., EMBO J. 5, 2623 (1986).
Giordano et al., Nature 339, 155 (1989).
Gohda et al., J. Clin. Invest. 81, 414-419 (1988).
Han et al., Biochem. 30, 9768-9780 (1991).
Igawa et al., Biochem. Biophys. Res. Commun. 174, 831-838 (1991).
Lindroos et al., Hepatol. 13, 734-750 (1991).
Matsumoto et al., Biochem. Biophys. Res. Commun. 176, 45-51 (1991).
Michalopoulos et al., Cancer Res. 44, 4414-4419 (1984).
Miyazawa et al., Eur. J. Biochem. 197, 15-22 (1991).
Miyazawa et al., Biochem. Biophys. Res. Comm. 163, 967-973 (1989).
Montesano et al., Cell 67, 901-908 (1991).
Nakamura et al., Biochem. Biophys. Res. Comm. 122, 1450-1459 (1984).
Nakamura et al., Proc. Natl. Acad. Sci. USA, 83, 6489-6493 (1986).
Nakamura et al., FEBS Letters 224, 311-315 (1987).
Nakamura et al., Nature 342, 440-443 (1989).
Naldini et al., Oncogene 6, 501-504 (1991).
Naldini et al., EMBO J. 10, 2867-2878 (1991).
Okajima et al., Eur. J. Biochem. 193, 375-381 (1990).
Park et al., Proc. Natl. Acad. Sci. USA 84, 6379-6383 (1987).
Rubin et al., Proc. Natl. Acad. Sci. USA 88, 415-419 (1991).
Russel et al., J. Cell Physiol. 119, 183-182 (1984).
Stoker et al., Nature 327, 239-242 (1987).
Tashiro et al., Proc. Natl. Acad. Sci. USA 87, 3200-3204 (1990).
Weidner et al., J. Cell Biol. 111, 2097-2108 (1990).
Wiman, B., Eur. J. Biochem. 76: 129-137 (1977).
JP 4,183,394 (Abstract) Jun. 30, 1992.
JP 4,030,000 (Abstract) Jan. 31, 1992.
JP 4,120,097 (Abstract) Apr. 21, 1992.
JP 4,036,189 (Abstract) Feb. 6, 1992.
JP 3,255,096 (Abstract) Nov. 13, 1991.
JP 3,204,899 (Abstract) Sep. 6, 1991.
JP 3,130,091 (Abstract) Jun. 3, 1991.
JP 2,288,899 (Abstract) Nov. 28, 1990.
JP 2,002,213 (Abstract) Jan. 5, 1990.
JP 1,027,491 (Abstract) Jan. 30, 1989.
JP 64,003,199 (Abstract) Jan. 6, 1989.
JP 62 161,730 (Abstract) Jul. 17, 1987.
JP 62,045,530 (Abstract) (with English translation) Feb. 27, 1987.
JP 60,045,534 (Abstract) Mar. 12, 1985.
JP 60,243,019 (Abstract) Dec. 3, 1985.
JP 4,013,696 (Abstract) Jan. 17, 1992.
JP 58,062,116 (Abstract) Apr. 13, 1983.
Godowski Paul J.
Lokker Natalie A.
Mark Melanie R.
Carlson K. Cochrane
Dreger Ginger R.
Genentech Inc.
Hill Jr. Robert J.
LandOfFree
Hepatocyte growth factor protease domain variants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatocyte growth factor protease domain variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatocyte growth factor protease domain variants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-395848