Hepatocyte growth factor (HGF) binding antibody

Details Hepatocyte growth factor (HGF) binding antibody Hepatocyte growth factor (HGF) binding antibody

2007-06-01

2010-02-09

Gambel, Phillip (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387100, C530S388100, C530S388150

Reexamination Certificate

active

07659378

ABSTRACT:
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

REFERENCES:
patent: 5707624 (1998-01-01), Nickoloff et al.
patent: 5766886 (1998-06-01), Studnicka et al.
patent: 5997868 (1999-12-01), Goldberg et al.
patent: 6432406 (2002-08-01), Goldberg et al.
patent: 6881557 (2005-04-01), Foote
patent: 7220410 (2007-05-01), Kim et al.
patent: 2008/0038256 (2008-02-01), Chung et al.
patent: 2008/0108565 (2008-05-01), Winston et al.
patent: WO-01/34650 (2001-05-01), None
patent: WO-2005/017107 (2005-02-01), None
patent: WO-2005/044848 (2005-05-01), None
patent: WO-2005/107800 (2005-11-01), None
patent: WO-2006/130773 (2006-12-01), None
patent: WO-2007/115049 (2007-10-01), None
Burgess et al. “Fully Human Monoclonal Antibodies to Hepatocyte Growth Factor With Therapeutic Potential Against Hepatocyte Growth Factor/C-Met-Dependent Human Tumors” (2006) Cancer Res. 66:3, pp. 1721-1729.
Burr et al. “Anti-Hepatocyte Growth Factor Antibody Inhibits Hepatocyte Proliferation During Liver Regeneration” Journal of Pathology, Chicester, Sussex, GB, vol. 185, (Jul. 1998) pp. 298-302.
Cao et al. “Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models” Proc. Natl. Acad. Sci. 2001 USA 98: 7443-7448.
Hwang et al. “Use of human germline genes in a CDR homology-based approach to antibody humanization” Methods. May 2005;36(1):35-42.
Kim et al. “Systemic anti-hepatocyte growth factor monoclonal antibody thereapy induces the regression of intracranial glioma axenografts” (2006) Clinical Cancer Research 12: 1292-1298.
R&D Systems, Inc. 1999 Catalog, p. 185, Cat. #MAB294, anti-human HGF monoclonal antibody.
Rubin et al. “Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product” Biochim Biophys Acta. Dec. 23, 1993;1155(3):357-71.
Studnicka et al. “Human-engineered monoclonal antibodies retain full specific binding activity by preserving non-CDR complementarity-modulating residues” Protein Eng. Jun. 1994;7(6):805-14.
Tan et al. ““Superhumanized” antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28” J Immunol. Jul. 15, 2002;169(2):1119-25.
Zaccolo et al. “Dimerization of FAB Fragments Enables Ready Screening of Phage Antibodies that Affect Hepatocyte Growth Factor/Scatter Factor Activity on Target Cells” European Journal of Immunology, vol. 27, No. 3, (1997), pp. 618-623.
International Search Report for PCT/2007/012950 dated Apr. 15, 2008.
International Search Report for PCT/2007/012939 dated Jan. 30, 2008.

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