Hepatocyte growth factor activating protease and gene encoding t

Details Hepatocyte growth factor activating protease and gene encoding t Hepatocyte growth factor activating protease and gene encoding t

1995-05-24

1997-10-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 435212, C12N 964

Patent

active

056771649

ABSTRACT:
A gene encoding a protease derived from human serum and having an activity to convert single-chain hepatocyte growth factor (HGF) into active two-chain HGF and a method of producing the protease by the use of said gene are provided. A method of producing a precursor protein of said protease is also provided.

REFERENCES:
patent: 4740461 (1988-04-01), Kaufman
Shimomura et al., "A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture", p. 1 Cytotechnology, vol. 8, No. 3, pp. 219-229, Sep. 24 1992.
Patent Abstracts of Japan, vol. 17, No. 446, Aug. 17, 1993, & JP-A-05 103 670 (Mitsubishi Kasei Corp) Apr. 27, 1993.
Naka et al., "Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer", Journal of Biological Chemistry, vol. 267, No. 28, pp. 20114-20119, Oct. 5, 1992.
Miyazawa et al., "Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor", Journal of Biological Chemistry, vol. 268, No. 14, pp. 10024-10028, May 15, 1993.
Journal of Biological Chemistry, "Activation of the Zymogen of Hepatocyte Growth Factor Activator by Thrombin" Shimomura et al., vol. 268, No. 30, Oct. 25, 1993, pp. 22927-22932.

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