Hepatocyte growth factor activating protease and gene encoding t

Details Hepatocyte growth factor activating protease and gene encoding t Hepatocyte growth factor activating protease and gene encoding t

1993-11-05

1995-11-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435226, 435691, 4352401, 4352523, 43525411, 4353201, 4351723, 536232, 935 14, 935 66, C12N 1557, C12N 1563, C12N 510

Patent

active

054665930

ABSTRACT:
A gene encoding a protease derived from human serum and having an activity to convert single-chain hepatocyte growth factor (HGF) into active two-chain HGF and a method of producing the protease by the use of said gene are provided. A method of producing a precursor protein of said protease is also provided.

REFERENCES:
patent: 4740461 (1988-04-01), Kaufman
Patent Abstracts of Japan, vol. 17, No. 446, Aug. 17, 1993, & JP-A-05 103 670 (Mitsubishi Kasei Corp) Apr. 27, 1993.
Naka et al., "Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer", Journal of Biological Chemistry, vol. 267, No. 28, pp. 20114-20119, Oct. 5, 1992.
Cytotechnology, "A Novel Protease Obtained from FBS-Containing Culture Supernatant, that Processes Single Chain form Hepatocyte Growth Factor to two Chain form in Serum-Free Culture" Shimomura et al., 8:219-229 (1992).
Journal of Biological Chemistry, "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor" Miyazawa et al., vol. 268, No. 14, May 15, 1993, pp. 10024-10028.
Journal of Biological Chemistry, "Activation of the Zymogen of Hepatocyte Growth Factor Activator by Thrombin" Shimomura et al., vol. 268, No. 30, Oct. 25, 1993, pp. 22927-22932.

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