Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1994-08-19
1996-08-13
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
A61K 3824, A61K 3827, A61K 31715, A61K 31725
Patent
active
055457223
ABSTRACT:
Disclosed is a hepatocyte-growth agent which comprises a polysaccharide or a derivative such as heparin, heparan sulfate, chondroitin sulfate and dextran sulfate and a hepatocyte-growth factor (hHGF) obtained by purification of plasma or recombination, by which activity of the hHGF is strengthened, and an hHGF molecule is stabilized.
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Arakaki et al., "Identification and Partial Characterization of Two Classes of Receptors for Human Hepatocyte Growth Factor On Adult rat Hepatocytes in Primary Culture," J. Biol. Chem. 267(10): 7101-7107 (1992).
Komada et al., "Characterization of hepatocyte-growth-factor receptors on Meth A cells," Eur. J. Biochem. 204: 857-864 (1992).
Roghani et al., "Basic Fibroblast Growth Factor Is Internalized through Both Receptor-mediated and Heparan Sulfate-mediated Mechanisms," J. Biol. Chem. 267(31): 22156-22162 (1992).
Zarnegar et al. "Purification and Biological Characterization of Human Hepatopoietin A, A Polypeptide Growth Factor For Hepatocytes", Cancer Research 49: 3314-3320 (1989).
Zarnegar et al."Identification and Partial Characterization of Receptor Binding Sites for HGF on Rat Hepatocytes", Biochem. Research Communications 173(3): 1179-1185 (1990).
Ruoslahtl et al. "Proteoglycans as Modulators of Growth Factor Activities", Cell 64: 867-869 (1991).
Larson Kristin
Mitsubishi Kasei Corporation
Wityshyn Michael G.
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