Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1984-05-03
1986-07-29
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436829, 4284022, 424 38, 514 3, A61K 4900
Patent
active
046030441
ABSTRACT:
A targeted drug delivery system which has specificity for hepatobiliary receptors, which are the specialized metabolic cells of the liver. Hereinafter, this will be referred to as a Hepatocyte Directed Vesicle, or abbreviated as HDV. This preferred directed delivery system utilizes a bipolar lipid for the majority of its vesicle membrane structure.
The targeting material, which is only a minor constituent of a targeted vesicle system, has a specificity for hepatobiliary receptors of the liver. The Hepatocyte Directed Vesicle is then attracted to the receptor, and the vesicle releases its pharmacological cargo.
This disclosure specifies that the attachment of the targeting material, or molecule, to the vesicle is preferably done by first providing a connector molecule, having a portion inserted into the wall of the vesicle, by reason of being lipophilic, and a portion which is hydrophilic and is projected from the vesicle wall.
The target, by connector molecules, are tied together to extend or project the target molecule a distance from the vescile wall.
Any chemical molecule capable of circulating in the bloodstream of a warm-blooded animal and attracted to the hepatobiliary receptors will serve as a target substance for this invention.
This invention is in the discovery of a unique and unprecedented result of directing a vesicle containing a pharmacological load to the hepatobiliary receptors.
REFERENCES:
patent: 4091088 (1978-05-01), Hunt et al.
patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4318898 (1982-03-01), Molter et al.
patent: 4377567 (1983-03-01), Geho
Geho W. Blair
Lau John R.
Brookes Anne
Lovering Richard D.
Technology Unlimited Inc.
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