Hepatitis E virus vaccine and method

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241921, 4241931, 4242281, 4242181, 935 65, A61K 3929

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active

057414904

ABSTRACT:
Antigen and antibody vaccine composition effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes a peptide corresponding to a carboxyl terminal end region of the capsid protein encoded by the second open reading frame 2 of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.

REFERENCES:
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Boyles, S., "Indian HEV Strain Shows High-Level Endemicity," Vaccine Weekly (Nov. 27, 1995).
Bradley, D.W., et al., "Enterically transmitted non-A, non-B hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27-to 34-nm viruslike particles", Proc. Natl. Acad. Sci. USA 84(17):6277-81 (1987).
Huang, C.-C., et al., "Molecular cloning and sequencing of the Mexico isolate of hepatitis", Virology 191(2):550-8 (1992).
Purdy, M.A., et al., "Expression of a hepatitis E virus (HEV)-trpE fusion protein containing epitopes recognized by antibodies in sera from human cases and experimentally infected primates", Archives of Virology 123(3-4):335-49 (1992).
Reyes, G.R., et al., "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis", Science 247(4948):1335-9 (1990).
Tam, A.W., et al., "Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome", Virology 185(1):120-31 (1991).
Yarbrough, P.O., et al., "Hepatitis E virus: identification of type-common epitopes", J. Virol. 65(11):5790-7 (1991).
Kaur, M., et al., "Human linear B-cell epitopes encoded by the Hepatitis E virus include determinants in the RNA-dependent RNA polymerase," Proc. Natl. Acad. Sci. USA 89: 3855-3858 (1992).

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