Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-06-13
1998-04-21
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241921, 4241931, 4242281, 4242181, 935 65, A61K 3929
Patent
active
057414904
ABSTRACT:
Antigen and antibody vaccine composition effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes a peptide corresponding to a carboxyl terminal end region of the capsid protein encoded by the second open reading frame 2 of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.
REFERENCES:
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Boyles, S., "Indian HEV Strain Shows High-Level Endemicity," Vaccine Weekly (Nov. 27, 1995).
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Bradley Daniel W.
Krawczynski Krzysztof Z.
Purdy Michael A.
Reyes Gregory R.
Tam Albert W.
Dehlinger Peter J.
Fabian Gary R.
Genelabs Technologies, Inc.
Mosher Mary E.
Sholtz Charles K.
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