Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-06-07
1998-06-23
Knode, Marian C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, 4242281, 4242751, 4241851, 4241891, 4241921, A61K 3800, A61K 3929, A61K 3900, C07K 500
Patent
active
057706891
ABSTRACT:
An antigen composition hepatitis E virus (HEV) infection are disclosed. The antigen composition includes peptides corresponding to carboxyl terminal end regions of the second and third open reading frames of the HEV genome.
REFERENCES:
patent: 4871659 (1989-10-01), Pillot
patent: 5202430 (1993-04-01), Brian et al.
patent: 5218099 (1993-06-01), Bradley et al.
Salynn Boyles, senior editor, report in Vaccine Weekly on Nov. 27, 1995, only 1 page, no page number given, Nov. 26, 1995.
Bradley, D.W., et al., "Enterically Transmitted Non-A, Non-B Hepatitis: Serial Passage of Disease in Cynomolgus Macaques and Tamarins and Recovery of Disease-Associated 27-to 34-nm Viruslike Particles," Proc. Natl. Acad. Sci. USA 84(17):6277-6281 (1987).
Dawson, G.J., et al., "Solid-Phase Enzyme-Linked Immunosorbent Assay for Hepatitis E Virus IgG and IgM Antibodies utilizing recombinant Antigens and Synthetic Peptides," J. Virol. Methods 38(1):175-186 (1992).
Huang, C.-C., et al., "Molecular Cloning and Sequencing of the Mexico Isolate of Hepatitis E Virus (HEV)", Virology 191(2):550-558 (1992).
Kaur, M., et al., "Human Linear B-Cell Epitopes Encoded by the Hepatitis E Virus Include Determinants in the RNA-Dependent RNA Polymerase," Proc. Natl. Acad. Sci. USA 89:3855-3858 (1992).
Khudyakov, Y.E., et al., "Epitope Mapping in Proteins of Hepatitis E Virus," Virology 194(4):89-96 (1993).
Lok, A.S.F., et al., "Comparison of Reactivity to ORF 2 and ORF 3 HEV Antigens in IgG and IgM Anti-HEV Assays," Int'l Symposium on Viral Hepatitis and Liver Disease (Scientific Program and Abstract Volume), Abstract 694, pp. 262 (1993).
Purdy, M.A., et al., "Expression of a Hepatitis E Virus (HEV)-trpE Fusion Protein Containing Epitopes Containing Epitopes Recognized by Antibodies in Sera From Human Cases and Experimentally Infected Primates," Archives of Virology 123(3-4):335-349 (1992).
Reyes, G.R., et al., "Isolation of a cDNA from the Virus Responsible for Enterically Transmitted Non-A, Non-B Hepatitis," Science 247(4948):1335-1339 (1990).
Tam, A.W., et al., "Hepatitis E Virus (HEV): Molecular Cloning and Sequencing of the Full-Length Viral Genome," Virology 185(1):120-132 (1991).
Tsarev, S.A., et al., "ELISA for Antibody to Hepatitis E Virus (HEV) Based on Complete Open-Reading Frame-2 Protein Expressed in Insect Cells: Identification of HEV Infection in Primates," J. Infect. Dis. 168(2):369-378 (1993).
Yarbough, P.O., et al., "Hepatitis E Virus: Identification of Type-Common Eptiopes," J. Virol. 65:11(5790-5797 (1991).
Bradley Daniel W.
Krawczynski Krzysztof Z.
Purdy Michael A.
Reyes Gregory R.
Tam Albert W.
Dehlinger Peter J.
Fabian Gary R.
Genelabs Technologies, Inc.
Knode Marian C.
The United States of America as represented by the Department of
LandOfFree
Hepatitis E virus ORF Z peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatitis E virus ORF Z peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis E virus ORF Z peptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1395432