Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-05-25
1999-08-03
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242281, 4242041, 530350, 530826, 435 693, A61K 3929, A61K 3912, C12N 1551, C07K 100
Patent
active
059322195
ABSTRACT:
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate possible protein products. The products encoded in one open reading frame, ORF5, are identified as viral polypeptides p24.sup..delta. and p27.sup..delta., of which the nuclear .delta. antigens in HDV infected liver is comprised. These products, as well as others encoded in ORFs 1, 2, 6, and 7 are produced in recombinant expression systems. The ORF5 products, in particular, are useful for HDV diagnosis and vaccines.
REFERENCES:
patent: 4619896 (1986-10-01), Shattuck et al.
patent: 4710463 (1987-12-01), Murray
patent: 4959462 (1990-09-01), Dijkema et al.
patent: 5225347 (1993-07-01), Goldberg et al.
patent: 5378814 (1995-01-01), Houghton et al.
Bergmann et al., "Antigens of hepatitis delta virus in the liver and serum of humans and animals," J. Infect. Diseases 154(4):702-706 (1986).
Bonino et al., "Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope," Hepatology 1:127-131 (1981).
Bonino et al., "Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope," J. Virol. 58(3):945-950 (1986).
Chen et al., "Structure and replication of the genome of the hepatitis delta virus," Proc. Natl. Acad. Sci. USA 83: 8774-8778 (1986).
Denniston et al., "Cloned fragment of the hepatitis delta virus RNA genome: Sequence and diagnostic application," Science 232:873-875 (1986).
Denniston et al., Biochem. Genetics 105:ref. 1518y (1986).
Hallewell et al. Proc. Natl. Acad. Sci 13(6):2017-2034.
Hoyer et al., "Properties of Delta-Associated Ribonucleic Acid," presented at the Turin Symposium, 1983.
Hoyer et al., "Evidence for non-A, non-B viruses," Chem. Abstracts: ref. 171213j (1984).
Jacobson et al., "Epidemiology and clinical impact of hepatitis D virus (Delta) infection," Hepatology 5:188-191 (1985).
Kos et al., "The hepatitis delta virus possesses a circular RNA," Nature 323(6088):558-560 (1986).
Rizzetto et al., "Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers," Gut 18:997-1003 (1977).
Rizzetto et al., "The hepatitis B virus-associated delta antigen: isolation from liver development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen," Proc. Natl. Acac. Sci. USA 77:6124-6128 (1980).
Rizzetto et al., "The hepatitis B virus-associated delta antigen: isolation from liver development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen," J. Immunol. 125(1):318-324 (1980).
Rizzetto et al., "Delta hepatitis--present status," (1985) J. Hepatology 1:187-193.
Schiff et al., "Delta agent: Another hepatitis virus," Diagnostic Medicine, pp. 17-22 (1985).
Valenzuela et al., "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast," Nature 298:347-350 (1982).
Wang et al., "Structure, sequence and expression of the hepatitis delta viral genome," Nature 323(6088):508-514 (1986).
Wickens et al., J. Biol. Chem. 253:2483-2375 (1978).
Gerin et al., Viral Hepatitis & Liver Disease, International Symposium on Viral Hepatitis & Liver Disease (8th:1993: Tokyo, Japan) Springer-Verlag Tokyo 1994, pp. 38-41.
Karayiannis et al., Hepatitis Delta Virus, vol., Wiley-Liss Inc, vol. 382, pp. 193-199, 1993.
Ponzetto et al. Hepatitis Delta Virus (1993) Wiley-Liss, Inc., 270-210.
Choo Qui-Lim
Houghton Michael
Overby Lacy Rasco
Wang Kang-Sheng
Weiner Amy Joan
Blackburn Robert P.
Chiron Corporation
Knode Marian C.
McClung Barbara G.
Robins Roberta L.
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