Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-07-27
1995-02-14
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 6, 435 691, 435 697, 435 712, 4351723, 4352351, 4352402, 4352523, 4353201, 536 231, 536 234, 536 2372, 536 2432, 935 3, 935 9, 935 10, 935 12, 935 24, 935 41, 935 43, 935 56, 935 72, 935 78, C12N 1551, C12N 1562, C12N 1563, C12N 121
Patent
active
053895282
ABSTRACT:
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate possible protein products. The products encoded in one open reading frame, ORF5, are identified as viral polypeptides p24.sup..delta. and p27.sup..delta., of which the nuclear .delta. antigens in HDV infected liver is comprised. These products, as well as others encoded in ORFs 1, 2, 6, and 7 are produced in recombinant expression systems. The ORF5 products, in particular, are useful for HDV diagnosis and vaccines.
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Choo Qui-Lim
Houghton Michael
Overby Lacy R.
Wang Kang-Sheng
Weiner Amy J.
Chiron Corporation
McClung Barbara G.
Prouty Rebecca
Robins Roberta L.
Wax Robert A.
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