Hepatitis delta diagnostics and vaccines

Details Hepatitis delta diagnostics and vaccines Hepatitis delta diagnostics and vaccines

1995-05-24

1998-05-05

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of antigens from multiple viral species

4241891, 4242281, 4242041, 4241861, 435 643, A61K 39295, A61K 3929, A61K 3912

Patent

active

057470448

ABSTRACT:
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate possible protein products. The products encoded in one open reading frame, ORF5, are identified as viral polypeptides p24.sup..delta. and p27.sup..delta., of which the nuclear .delta. antigens in HDV infected liver is comprised. These products, as well as others encoded in ORFs 1, 2, 6, and 7 are produced in recombinant expression systems. The ORF5 products, in particular, are useful for HDV diagnosis and vaccines.

REFERENCES:
patent: 4619896 (1986-10-01), Shattuck et al.
patent: 4710463 (1987-12-01), Murray
patent: 4722840 (1988-02-01), Valenzuela et al.
patent: 4959462 (1990-09-01), Dijkema et al.
patent: 5225347 (1993-07-01), Goldberg et al.
patent: 5378814 (1995-01-01), Houghton et al.
Machein et al. (Arch. Virol. Suppl. 4 : 133-136, 1992.).
Valenzuela et al. Biotechnology vol. 3 : 323-326, Apr. 1985.
Ponzetto et al. Hepatitis Delta Virus (1993) Wiley-Liss, Inc., pp. 207-210.
Stranding et al. Prol. Natl. Acad. Sci. USA, 83:9338-9342, Dec. 1986.
Bergmann et al., "Antigens of hepatitis delta virus in the liver and serum of humans and animals," J. Infect. Diseases 154(4): 702-706 (1986).
Bonino et al., "Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope," Hepatology 1:127-131 (1981).
Bonino et al., "Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope," J. virol. 58(3):945-950 (1986).
Delpeyroux et al., "A Poliovirus Neutralizaiton Epitope Expressed on Hybrid Hepatitis B Surface Antigen Particles," Science 233:472-475 (1986).
Chen et al., "Structure and replication of the genome of the hepatitis delta virus," Proc. Natl. Acad. Sci. USA 83:8774-8778 (1986).
Denniston et al., "Cloned fragment of the hepatitis delta virus RNA genome: Sequence and diagnostic application," Science 232:873-875 (1986).
Denniston et al., Biochem. Genetics 105:ref. 1518y (1986).
Hallewell et al. Proc. Natl. Acad. Sci 13(6):2017-2034.
Hoyer et al., "Properties of Delta-Associated Ribonucleic Acid," presented at the Turin Symposium, 1983.
Hoyer et al., "Evidence for non-A, non-B viruses," Chem. Abstracts: ref. 171213j (1984).
Jacobson et al., "Epidemiology and clinical impact of hepatitis D virus (Delta) infection," Hepatology 5:188-191 (1985).
Kos et al., "The hepatitis delta virus possesses a circular RNA," Nature 323(6088):558-560 (1986).
Rizzetto et al., "Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers," Gut 18:997-1003 (1977).
Rizzetto et al., "The hepatitis B virus-associated delta antigen: isolation from liver development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen," Proc. Natl. Acac. Sci. USA 77:6124-6128 (1980).
Rizzetto et al., "The hepatitis B virus-associated delta antigen: isolation from liver development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen," J. Immunol. 125(1):318-324 (1980).
Rizzetto et al., "Delta hepatitis--present status," (1985) J. Hepatology 1:187-193.
Schiff et al., "Delta agent: Another hepatitis virus," Diagnostic Medicine, pp. 17-22 (1985).
Valenzuela et al., "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast," Nature 298:347-350 (1982).
Wang et al., "Structure, sequence and expression of the hepatitis delta viral genome," Nature 323(6088):508-514 (1986).
Wickens et al., J. Biol. Chem. 253:2483-2375 (1978).

Affiliated with

Also associated with

Rating

Hepatitis delta diagnostics and vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hepatitis delta diagnostics and vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis delta diagnostics and vaccines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-51167