Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-05-24
1998-05-12
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 5, 4241861, 4241891, G01N 3353, C12Q 170, A61K 3921, A61K 3929
Patent
active
057503508
ABSTRACT:
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA Of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate possible protein products. The products encoded in one open reading frame, ORF5, are identified as viral polypeptides p24.sup..delta. and p27.sup..delta. of which the nuclear .delta. antigens in HDV infected liver is comprised. These products, as well as others encoded in ORFs 1, 2, 6, and 7 are produced in recombinant expression systems. The ORF5 products, in particular, are useful for HDV diagnosis and vaccines.
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Choo Qui-Lim
Houghton Michael
Overby Lacy Rasco
Wang Kang-Sheng
Weiner Amy Joan
Blackburn Robert P.
Chiron Corporation
Knode Marian C.
McClung Barbara G.
Robins Roberta L.
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