Hepatitis-C virus type 4, 5, and 6

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C530S326000, C530S402000, C530S403000, C530S806000, C530S811000, C530S826000, C424S184100, C424S185100, C424S186100, C424S189100, C424S192100, C424S204100, C424S225100, C424S228100, C435S005000, C435S007100, C436S501000, C436S518000, C436S524000, C436S536000, C436S086000, C436S811000, C436S820000, C436S825000

Reexamination Certificate

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06881821

ABSTRACT:
Newly elucidated sequences of hepatitis C virus type 4 and type 5 are described, together with those of a newly discovered type 6. Unique type-specific sequences in the NS4, NS5 and core regions enable HCV detection and genotyping into types 1 to 6. Antigenic peptides and immunoassays are described.

REFERENCES:
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patent: WO 9511918 (1994-10-01), None
Farci, Gastroenterology 104(4):1228-1229, Apr. 1993.*
Prince FEMS Mircrobiology Reviews 14:273-278, 1994.*
Marguerite et al. Mol. Immunol. 29(6):793-800, 1992.*
P. Simmonds et al;Sequence variability in the 5′ non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity, Journal of General Virology, 74, pp 661-668 (1993).
S.W. Chan et al;Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants, Journal of General Virology, 73, pp 1131-1141 (1992).
T.A. Cha et al;At least five related, but distinct, hepatitis C viral genotypes exist, Proceedings of the National Academy of Sciences of USA, 89, pp 7144-7148 (1992).
P. Simmonds et al;Classification of hepatitis C virus into six major genotypes and a series of subtypes of phylogenetic analysis of the NS-5 region, 74, pp 2391-2399 (1993).

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