Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-06-07
2000-02-01
Scheiner, Laurie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 691, 435 711, 500350, 4241891, 4242281, C12Q 170
Patent
active
060201223
ABSTRACT:
This invention provides a novel mammalian expression system that is capable of generating high levels of expressed hepatitis C virus (HCV) proteins which have previously proved difficult to express due to their non-secretory properties. In particular, the invention provides a plasmid for the expression of the HCV second envelope protein (E2) designated p577. This plasmid encodes a recombinant protein comprising the immunoglobulin signal peptide and amino acids 388-664 of the HCV E2 glycoprotein. This unique expression system produces high levels of HCV proteins that are properly processed, glycosylated, and folded.
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Newman et al., 1995, Vaccine Design: The Subunit and Adjuvant Approach, Powell et al., eds., Plenum Press, New York, pp. 1-42.
Graham et al., 1995, New Engl. J. Med. 333:1331-1339.
Prince, 1994, FEMS Microbiol. Rev. 14:273-278.
Lesniewski et al., 1995, J. Med. Virol. 45:415-422.
Yokosuka et al., 1993, Gut supplement:S64-S65.
Harada et al., 1995, J. Gen. Virol. 76:1223-1231.
Lesniewski Richard R.
Okasinski Gregory F.
Schaefer Verlyn G.
Suhar Thomas S.
Abbott Laboratories
Becker Cheryl L.
Parkin Jeffrey S.
Porembski Priscilla
Scheiner Laurie
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