Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-05-12
1997-01-28
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 772, 435 76, 435219, 536 232, 536 2372, C12Q 137, C12N 950, C12N 1557, C12N 1551
Patent
active
055976913
ABSTRACT:
The protease necessary for polyprotein processing in Hepatitis C virus is identified, cloned, and expressed. Proteases, truncated protease, and altered proteases are disclosed which are useful for cleavage of specific polypeptides, and for assay and design of antiviral agents specific for HCV.
REFERENCES:
patent: 4673634 (1987-06-01), Seto et al.
patent: 4702909 (1987-10-01), Vallarejos et al.
patent: 4870026 (1989-09-01), Wands et al.
patent: 4952493 (1990-08-01), Kettner et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5176994 (1993-01-01), Mishiro et al.
patent: 5218099 (1993-06-01), Reyes et al.
patent: 5350671 (1994-09-01), Houghton et al.
patent: 5371017 (1994-12-01), Houghton et al.
Korant, B. D., "Viral proteases: An emerging therapeutic target" CRC Critical Reviews in Biotechnology (1988) 8:149-157.
Pichuantes, S., et al., "Expression of authentic and enzymatically active HIV-1 proteinase in bacteria and yeast" Current Communications in Molecular Biology, Kr ausslich, H., et al., eds., Cold Spring Harbor Laboratory Press, (1989) pp. 215-222.
McQuade, T. J., et al., "A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation" Science (1990) 247:454-456.
Kubo, Y., et al., "A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan" EMBL Data Library Accession #S06067 Submitted: (Sep. 1989) Dated: (Feb. 28, 1990).
Kubo, Y., et al., "A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan" Nucleic Acids Research (1989) 17:10367-10372.
Miller, R. H., et al., "Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups" Proceedings of the National Academy of Science USA (1990) 87:2057-2061.
Inchauspe, G., et al., Proceedings of the National Academy of Sciences, U.S.A., vol. 88, "Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates", pp. 10292-10296 1991.
Choo, Q.-L., et al., Proceedings of the National Academy of Sciences, U.S.A., vol. 88, "Genetic organization and diversity of the hepatitis C virus", pp. 2451-2455 1991.
Kato, N., et al., Proceedings of the National Academy of Sciences, U.S.A., vol. 87, "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis", pp. 9524-9528 1990.
Takamizawa, A., et al., Journal of Virology, vol. 65, "Structure and organization of the hepatitis C virus genome isolated from human carriers", pp. 1105-1113 1991.
Okamoto, H., et al., Journal of General Virology, vol. 72, "Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions", pp. 2697-2704 1991.
Grakoui, A., et al., Proceedings of the National Academy of Sciences, U.S.A., vol. 90, "A second hepatitis C virus-encoded proteinase", pp. 10583-10587 1993.
Chambers, T. J., et al., Proceedings of the National Academy of Science, U.S.A., vol. 87, "Evidence that the N-terminal domain of yellow fever virus NS3 protein is a serine protease . . . ", pp. 8898-8902 1990.
Hijikata, M., et al., Journal of Virology, vol. 67, "Two distinct proteinase activities required for the processing of putative nonstructural precursor protein of hepatitis C virus", pp. 4665-4675 1993.
Choo Qui-Lim
Houghton Michael
Kuo George
Blackburn Robert P.
Chiron Corporation
Goldman Kenneth M.
Harbin Alisa A.
Moore William W.
LandOfFree
Hepatitis C virus protease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatitis C virus protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis C virus protease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-940743