Chemistry: molecular biology and microbiology – Vector – per se
Patent
1991-04-04
1994-12-06
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Vector, per se
536 232, 536 234, 536 2372, 435 691, 435 697, C12N 1500
Patent
active
053710177
ABSTRACT:
The protease necessary for polyprotein processing in Hepatitis C virus is identified, cloned, and expressed. Proteases, truncated protease, and altered proteases are disclosed which are useful for cleavage of specific polypeptides, and for assay and design of antiviral agents specific for HCV.
REFERENCES:
patent: 4673634 (1987-06-01), Seto et al.
patent: 4702909 (1987-10-01), Villarejos et al.
Y. Kubo, K. Takeuch, S. Boonmar, Q. L. Choo, G. Kuo, M. Houghton, I. Saito & T. Miyamura "cDNA Fragment of Hepatitis C Virus . . . " EMBL Data Library Accession #506067 Feb. 28, 1990.
Korant et al., CRC Crit. Rev. Biotech. (1988) 8:149-157.
Krausslich, H. et al., Eds., Current Communications in Molecular Biology article by Pichuantes et al., entitled "Viral Proteases as Targets for Chemotherapy" Cold Spring Harbor Laboratory Press, (1989) pp. 215-222.
McQuade et al., Science (1990) 247:454-456.
Choo Qui-Lim
Houghton Michael
Kuo George
Blackburn Robert P.
Chiron Corporation
Draper Garnette D.
Goldman Kenneth M.
Green Grant D.
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