Hepatitis C virus epitopes

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 5, 4352528, 4241891, 536 2372, C12P 2106, C12Q 170, A61K 3929, C07H 1700

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054439655

ABSTRACT:
Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.

REFERENCES:
patent: 4464474 (1984-08-01), Coursaget
patent: 5350671 (1994-09-01), Houghton et al.
Jacob, J. R., et al., J. Infect. Dis. 161:1121-1127 (1990).
Kuo, G., et al., Science 244:362 (1989).
Van Der Poel, C. L., et al., Lancet 337:317 (1991).

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