Hepatitis C virus epitopes

Details Hepatitis C virus epitopes Hepatitis C virus epitopes

1992-03-20

1995-07-25

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530826, 435 5, 435697, 4352351, 4353201, 536 2372, C07K 1504, C12Q 170, C12P 2106, C07H 1700

Patent

active

054363187

ABSTRACT:
Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.

REFERENCES:
patent: 4464474 (1984-08-01), Coursaget
Choo et al., "Genetic organization and diversity of the hepatitis C virus", Proc. Natl. Acad. Sci. 88:2451-55 (1991).
Choo et al., "Hepatitis C virus: The major causative agent of viral non-A, non-B hepatitis," Br. Med. Bull 46:423-441 (1990).
Miller et al., "Hepatitis C virus shares amino acid sequence simularity with postivirus and flairviruses as well as members of two plant virus supergroups," Proc. Natl. Acad. Sci 87:2057-2061 (1990).
Jacob, J. R., et al., J. Infect. Dis. 161:1121-1127 (1990).
Kuo, G., et al., Science 244:362 (1989).
Van Der Poel, C. L., et al., Lancet 337:317 (1991).

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