Hepatitis C virus epitopes

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 5, 530350, C12P 2106, C12Q 170, C07K 1418

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active

055388655

ABSTRACT:
Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.

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Choo, Q.-L., et al., "Isolation of a cDNA Clone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome," Science 244:359 (1989).
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He, L.-F., et al., "Determining the Size of Non-A, Non-B Hepatitis Virus by Filtration," J. Infect. Dis. 156(4):636 (1987).
Kuo, G., et al., "An Assay for Circulating Antibodies to a Major Etiologic Verus of Human Non-A, Non-B Hepatitis," Science 244:362 (1989).
Maeno, M., et al., "A cDNA clone closely associated with non-A, non-B hepatitis," Nucl. Acids Res. 18(9):2685 (1990).

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