Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-05-17
2000-06-13
Wortman, Donna C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 5, 4241851, 4242281, 530395, 530826, C12Q 170, C12P 2104, A61K 3929
Patent
active
060748524
ABSTRACT:
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
REFERENCES:
patent: 5350571 (1994-09-01), Houghton et al.
Rudolph et al., "The Yeast Secretory Pathway . . . ," Cell 58:133-145 (1989).
Sleep et al., "The Secretion of Human Serum . . . ," Bio/Techology 8: 42-46 (1990).
Goochu et al., "The Oligosaccharides of Glycoproteins:," Bio/Technology 9: 1347-1355 (1991).
Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technololgy, p. 138 (1987).
Berger Kim M.
Choo Qui-Lim
Gervase Barbara A.
Hall John A.
Houghton Michael
Blackburn Robert P.
Chiron Corporation
Harbin Alisa A.
Robins Roberta L.
Wortman Donna C.
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