Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-05-17
1999-08-24
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241851, 435 5, 435 692, 435 699, 530395, 530826, F61K 3929, C12P 2162, C12Q 170, C07K 100
Patent
active
059422343
ABSTRACT:
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
REFERENCES:
patent: 5350671 (1994-09-01), Houghton et al.
Lanford et al., "Analysis of Hepatitis C Virus Capsid, E1, and E2/NS1 Proteins Expressed in Insect Cells," Virology 197:225-235 (1993).
Spaete et al., "Characterization of the Hepatitis C Virus E2/NS1 Gene Product Expressed in Mammalian Cells," Virology 188:819-830 (1992).
Koff, "A redoubtable obstacle to a Hepatitis C vaccine," Gastroenterology 104:1228-1229 (1993).
Farci et al., "Lack of protective immunity against reinfection with Hepatitis C virus," Science 258:135-140 (1992).
Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology (W.B. Saunders Company, Philadelphia) p. 138 (1987).
Goochee et al., "The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties," Bio/Technology 9:1347-1353 (1991).
Berger Kim M.
Choo Qui-Lim
Gervase Barbara A.
Hall John A.
Houghton Michael
Blackburn Robert P.
Chiron Corporation
Harbin Alisa A.
Woodward Michael P.
Zeman Mary K
LandOfFree
Hepatitis C virus asialoglycoproteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatitis C virus asialoglycoproteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis C virus asialoglycoproteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-464352