Hepatitis C receptor protein CD81

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S005000, C435S007200, C435S007210, C530S300000, C530S350000, C514S002600

Reexamination Certificate

active

07097987

ABSTRACT:
The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for such purposes.

REFERENCES:
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patent: WO 96/05513 (1996-02-01), None
patent: WO 97/09349 (1997-03-01), None
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Fearon, D.T., and Carter, R.H., “The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity,”Annu. Rev. Immunol. 13:127-149 (1995).
Guan et al., “Eukaryotic Proteins Expressed inEscherichia coli: An Improved Thrombin Cleavage and Purification Procedure of Fusion Proteins with Glutathione S-Transferase”, Anal. Biochem., 192:262-267 (1991).
Levy et al., “CD81 (TAPA-1): A Molecule Involved in Signal Transduction and Cell Adhesion in the Immune System,”Annu. Rev. Immunol. 16:89-109 (1998).
Mannion et al., Transmembrane-4 Superfamily Proteins CD81 (TAPA-1), CD82, CD63 and CD53 Specifically Associated with Integrin (CD49d/CD29), J. Immunol., 157:2039 (1996).
Oren et al., “Tapa-1, thc Target of an Antiproliferative Antibody, Defines a New Family of Transmembrane Proteins,”Molecular and Cellular Biology10(8):4007-4015 (1990).
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Rosa, D. et al., “A Quantitative Test to Estimate Neutralizing Antibodies to the Hepatitis C Virus: Cytofluorimetric Assessment of Envelope Glycoprotein 2 Binding to Target Cells,”Proc. Natl. Acad. Sci. U.S.A. 93(3):1759-1763 (1996).

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