Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-06-27
2006-06-27
Housel, James (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C530S820000, C530S826000, C530S806000, C530S350000, C424S185100, C424S186100, C424S189100, C536S023100, C536S023700, C536S023720
Reexamination Certificate
active
07067247
ABSTRACT:
We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both for HBsAg and anti-HBs Antibody (Ab) with an equally long-lasting anti-HB core (c) IgM Ab.
REFERENCES:
Partial European Search Report, dated Aug. 21, 2001, for EPO Application No. 01 30 3073.
Norder, H. et al.: “Comparison of the Amino Acid Sequences of Nine Different Serotypes of Hepatitis B Surface Antigen and Genomic Classification of the Corresponding Hepatitis B Virus Strains”, J Gen Virology, May 1992, vol. 73 (P1 5), 1201-1208.
Noder, H. et al.: “Subtypes, Genotypes and Molecular Epidemiology of the Hepatitis B Virus as Reflected by Sequence Variability of the S-Gene”, Intervirology 1995, vol. 38, 24-34.
Stirk, H.J. et al.; “A Topological Model for Hepatitis B Surface Antigen”, Intervirology, 1992; vol. 33, 148-158.
Wienberger, K.M. et al.: “Hepatitis B Virus Isolate WR2209 Small Surface Antigen (s) Gene, Complate CDs”, DATABASE EMBL : AF208877, Jan. 11, 2000, XP002173120.
Antar Stacey B.
Housel James
Ortho-Clinical Diagnostics, Inc.
Peng Bo
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