Hepatitis B virus surface antigen mutant and methods of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S320100, C435S325000, C424S189100, C424S227100

Reexamination Certificate

active

09821877

ABSTRACT:
The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.

REFERENCES:
patent: 5464933 (1995-11-01), Bolognesi et al.
patent: 5593825 (1997-01-01), Carman et al.
patent: 5595739 (1997-01-01), Carman et al.
patent: 5762938 (1998-06-01), Paoletti et al.
patent: 5925512 (1999-07-01), Carman et al.
patent: 0 374 869 (1990-06-01), None
patent: 0 919 568 (1999-06-01), None
Carman, et al.,Gastroenterology,Gentic Variation in Hepatitis B Virus, 102:711-719 (1992).
Carman, et al.,Lancet,Viral Genetic Variation: Hepatitis B Virus as a Clinical Example, 341:349-353 (1993).
Courouce, et al.,Bibliotheca Haematologica,The a(w) Subdeterminants, 42:31-41 (1976).
Gerlich, et al.,In Viral Hepatitis and Liver Disease,Functions of Hepatitis B Virus Proteins and Virus Assembly, Holinger, et al,., eds. Williams-Wilkens, Baltimore, MD, 121-134 (1991).
Okamoto, et al.,Pediatric Research,Mutations Within the S Gene of Hepatitis B Virus Transmitted from Mothers to Babies Immunized with Hepatitis B immune Globulin and Vaccine, 32:264-268 (1992).
Tiollais, et al.,Nature,The Hepatitis B Virus, 317:489-495 (1985).
Coleman, P.F., et al., “Innumoassay Detection of Hepatitis B Surface Antigen Mutants”,Journ of Med Virology,59:19-24 (1999).
Norder, H., et al., “Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains”,Journ of Gen Virology,73:1201-1208 (1992).
Peterson, D.L., et al., “Antigenic Structure of Hepatitis B Surface Antigen: Identification of the “d” Subtype Determinant by Chemical Modification and Use of Monoclonal Antibodies”,The Journ of Immun,132(2):920-927 (1984).
Qui, X., et al., Identification and Characterization of a C(D/R)TC Motif as a Common Epitope Present in All Subtypes of Hepatitis B Surface Antigen,Journ of Immunol,156(9):3350-3356 (1996).
Zhang, Y-Y, et al., “Increasing Heterogeneity of the ‘a’ Determinant of HbsAg Found in the Presumed Late Phase of Chronic Hepatitis B Virus Infection”,Scand J Infec Dis,28:9-15 (1996).
Coleman, P., “Epitope Analysis of a Novel Hepatitis B Surface Antigen Mutant”, Antiviral Therapy 2000; 5 (Suppl. 1), p. B.6 (10thIntl. Symposium on Viral Hepatitis and Liver Disease, Apr. 9-13, 2000, Atlanta, USA , (Abstract B008).

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