Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-11-28
2006-11-28
Li, Bao Qun (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C435S975000, C435S005000, C530S350000, C530S826000
Reexamination Certificate
active
07141242
ABSTRACT:
The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
REFERENCES:
patent: 5464933 (1995-11-01), Bolognesi et al.
patent: 5593825 (1997-01-01), Carman et al.
patent: 5595739 (1997-01-01), Carman et al.
patent: 5925512 (1999-07-01), Carman et al.
patent: 6172193 (2001-01-01), Primi et al.
Coleman et al., Journal of Medical Virology 59: 19-24 (1999).
Coleman P, Emerging Infectious Diseases 2006, Feb. 12, No. 2, pp. 1-10.
Lai et al. Nucleic acids Research, 1991, vol. 19, No. 18, pp. 5078.
Hepatitis B surface antigen seqeunces published on Jan. 4, 2006 by NCBI: Q773S4, AAO12662, Q67886, AAT28717, 28718, and AAT28719.
Carman, et al.,Gastroenterology, Gentic Variation in Hepatitis B Virus, 102:711-719 (1992).
Carman, et al.,Lancet, Viral Genetic Variation: Hepatitis B Virus as a Clinical Example, 341:349-353 (1993).
Courouce, et al.,Bibliotheca Haematologica, The a(w) Subdeterminantst, 42:31-41 (1976).
Gerlich, et al.,In Viral Hepatitis and Liver Disease, Functions of Hepatitis B Virus Proteins and Virus Assembly, Holinger, et al,., eds. Williams-Wilkens, Baltimore, MD, 121-134 (1991).
Okamoto, et al.,Pediatric Research, Mutations Within the S Gene of Hepatitis B Virus Transmitted from Mothers to Babies Immunized with Hepatitis B immune Globulin and Vaccine, 32:264-268 (1992).
Tiollais, et al.,Nature, The Hepatitis B Virus, 317:489-495 (1985).
Coleman Paul F.
Mushahwar Isa K.
Abbott Laboratories
Becker Cheryl L.
Li Bao Qun
LandOfFree
Hepatitis B virus surface antigen mutant and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatitis B virus surface antigen mutant and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis B virus surface antigen mutant and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3622386