Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1993-05-07
1997-01-21
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242271, 435 5, 435975, 4352351, 530324, 530350, 530403, 930220, A61K 3929, G01N 33543, C07K 1402, C12Q 170
Patent
active
055957390
ABSTRACT:
Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.
REFERENCES:
patent: 5279944 (1994-01-01), Fabrizi et al.
Hiroaki Okamoto et al., "The Loss of Subtypic Determinants in Alleles, d/y Or w/r, On Hepatitis B Surface Antigen" Molecular Immunology, vol. 26, No. 2, pp. 197-205 (1989).
William Carman, et al, "Viral genetic variation: hepatitis B virus as a clinical example" The Lancet, vol. 341:349-353 (1993).
William F. Carman, et al, "Vaccine-induced escape mutant of hepatitis B virus." Medical Science vol. 336:325-329 (1990).
Tim J. Harrison et al., "Variants of Hepatitis B Virus" Vox Sang 1992; 63:161-167.
K. Yamamoto, et al., "Naturally Occurring Escape Mutants of Hepatitis B Virus with Various Mutations in the S Gene in Carriers Seropositive for Antibody to Hepatitis B Surface Antigen", J. Virol., vol. 68 No. 4:2671-2676 (1994).
W. F. Carman, et al., "Genetic Variation in Hepatitis B Virus", Gastroenterology, vol. 102:711-719 (1992).
Ashton-Rickardt, P. et al, "Mutants of the Hepatitis B Virus Surface Antigen That Define Some Antigenically Essential Residues in the Immunodominant a Region", Journal of Medical Virology, 29:196-203 (1989).
Carman William F.
Decker Richard H.
Mimms Larry T.
Solomon Larry R.
Wallace Lesley
Abbott Laboratories
Mosher Mary E.
Porembski Priscilla E.
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