Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-05-23
1997-01-14
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
536 2372, 536 2432, 4353201, 4352401, 4352523, 43525411, 435 693, 435975, C12Q 170, C12N 1536
Patent
active
055938256
ABSTRACT:
Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.
REFERENCES:
patent: 5279944 (1994-01-01), Fabrizi et al.
Hiroaki Okamoto et al., "The Loss of Subtypic Determinants in Alleles, d/y Or w/r, On Hepatitis B Surface Antigen" Molecular Immunology, vol. 26, No. 2, pp. 197-205 (1989).
William Carman, et al, "Viral genetic variation: hepatitis B virus as a clinical example" The Lancet, vol. 341:349-353 (1993).
William F. Carman, et al, "Vaccine-induced escape mutant of hepatitis B virus." Medical Science vol. 336:325-329 (1990).
Tim. J. Harrison et al., "Variants of Hepatitis B Virus" Vox Sang 1992;63:161-167.
Philip G. Ashton-Rickardt et al., "Mutants of the Hepatitis B Virus Surface Antigen That Define Some Antigenically Essential Residues in the Immunodominant a Region" Journal of Medical Virology 29:196-203 (1989).
K. Yamamoto, et al., "Naturally Occurring Escape Mutants of Hepatitis B Virus with Various Mutations in the S Gene in Carriers Seropositive for Antibody to Hepatitis B Surface Antigen", J. Virol., vol. 68 No. 4:2671-2676 (1994).
W. F. Carman, et al., "Genetic Variation in Hepatitis B Virus", Gastroenterology, vol. 102: 711-719 (1992).
Carman William F.
Decker Richard H.
Mimms Larry T.
Solomon Larry R.
Wallace Lesley
Abbott Laboratories
Mosher Mary E.
Porembski Priscilla E.
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