Hepatitis B vaccine

Details Hepatitis B vaccine Hepatitis B vaccine

1994-11-07

1997-06-17

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4241891, 4242271, 530350, C12N 119, A61K 3929, C07K 1402

Patent

active

056396376

ABSTRACT:
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.

REFERENCES:
patent: 4738926 (1988-04-01), Hamada et al.
McMahon, et al, Cold Spring Harbour Symposium, (Sep. 1989).
Carman et al. British Application 9007024.4.
Boslego, J.W. et al In: "Vaccines and Immunotherapy" Cruz, S.J. Ed. Pergaman Press pp. 211-223 (1991).
Ellis, R.W. In:Vaccines Protein, S.A. +Mortimer, E.A. Eds. W.B. Saunders Co. (1988) pp. 558-575.
Bovice, J.V. et al. Science 247:1306-1310 (1990).
Kumar, V. et al. Proc. Natl. Acad. Sci. 87:1337-1341 (1990).
Watus, J.A. et al. J. Clin. Invest. 90(6): 2543-7 (1992).
Okamato, H. et al. Mol. Immunol. 26(2):17-205 (1989).
Carman, W.F. et al. Lancet 336: 325-329 (1990).
Zanetti, A.R. et al. Lancet Nov. 12, 1988, pp. 1132-1133.

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