Hepatitis B vaccine

Details Hepatitis B vaccine Hepatitis B vaccine

1997-03-10

1998-12-22

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 435 693, 536 2372, C12N 1551, C12P 2102, C07H 2104

Patent

active

058518231

ABSTRACT:
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAG antibodies.

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Kumar, V. et al. "Amino acid variations at a single . . . " Proc. Natl Acad. Sci. 87:1337-1341 (1990).

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