Hepatitis B vaccine

Details Hepatitis B vaccine Hepatitis B vaccine

1997-02-21

1999-11-23

Smith, Lynette F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 5, 4353201, 435810, 435975, 530350, 436820, C12P 2106, C12Q 170, G01N 3353, G01N 33576

Patent

active

059898658

ABSTRACT:
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is dicslosed, in which the variant protein of fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.

REFERENCES:
patent: 4738926 (1988-04-01), Hamada et al.
Valenzuela et al. "Nucleotide sequence of the gene..." Nature, 280 (1979), pp.815-819.
McMahon et al. "DNA Sequence analysis of surface..." Cold Spring Harbour symposium, (Sep. 1989).
Carman et al. British application 9007024.4.
Waters, J.S. et al."Loss of the common "A" determinant.." J. Clin. Invest. 90(6) (1992), pp. 2543-2547.
Okamoto, H. et al. Mol. Immunol. 26(2): 197-205 (1989).
Carman, W.F. et al. Lancet 356:325-329 (1990).
Zenetta A.R. et al. Lancet Nov. 12, 1988, pp. 1132-1133.
Boslego, J.W. et al. "Gonorrhea vaccines" Vaccines and Immunol. Cryz, S.J. ed. Pergamon Press, (1991)pp. 211-223.
Ellis, R.W. "New technologies for..." Vaccines, Plotkin, S.A. et al, eds. Saunders & Co. (1988) pp. 588-575.
Bowie, J.U. et al. "Deciphering the message..." Science, 247: 1306-1310 (1990).
Kumar, V. et al. "Amino acid variations at a single..." Proc. Natl Acad. Sci. 87:1337-1341 (1990).

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