Hepatitis B vaccine

Details Hepatitis B vaccine Hepatitis B vaccine

1995-06-07

2000-08-08

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

4241591, 4241611, 4241891, 4242271, 5303879, 5303883, 5303894, C07K 1600, C12P 2108, A61K 3942

Patent

active

060998407

ABSTRACT:
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified a determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as it is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.

REFERENCES:
Ashton-Rickardt et al., "Mutants of the Hepatitis B Virus Surface Antigen . . . ," J Med Virol. 29:196-203(1989).
Zanetti et al., "Hepatitis B Variant in Europe," The Lancet, Nov. 12, 1988 : 1132-33.

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