Hepatitis B vaccine

Details Hepatitis B vaccine Hepatitis B vaccine

1988-08-29

1991-05-28

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 424 858, 530326, 530300, 514 2, 514 13, A61K 3929, C07K 708

Patent

active

050193864

ABSTRACT:
A polypetide vaccine is disclosed with the amino acid sequence of Asp-Pro-Arg-Val-Arg-Gly-Leu-Try-Phe-Pro-Ala-Gly-Gly-Ser-Ser-Ser-Gly-Thr-Va l that bears the receptor for polymerized human serum albumin capable of raising antibodies to inhibit the access and entry of hepatitis B virus (HBV) to hepatocytes. The polypeptide vaccine is also shown in which the 9th amino acid residue (Phe) is replaced by leucine. In addition, there is disclosed hepatitis B polypeptide vaccine P31 which is capable of raising antibodies to block the attachment of HBV to hepatocytes.

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