Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-07
2000-09-12
Eisenschenk, Chris
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4241891, 5303951, 536 2372, C12Q 170, G01N 3353
Patent
active
061176532
ABSTRACT:
HBV surface antigen particles, prepared by recombinant DNA technology are described, said particles being composed of epitopes from the group of surface peptides and/or core peptide of non-A, non-B hepatitis virus, hepatitis virus A and/or hepatitis virus B. Respective particles are especially characterized by a composition of different epitopes selected from pre-S and S peptides. There are also described DNA-sequences, plasmids and cell lines coding for respective HBV surface antigen particles as well as a new vaccine containing the same.
REFERENCES:
patent: Re34705 (1994-08-01), Galibert et al.
patent: 3636191 (1972-01-01), Blumberg et al.
patent: 4415491 (1983-11-01), Vyas
patent: 4428941 (1984-01-01), Galibert et al.
patent: 4563423 (1986-01-01), Murray et al.
patent: 4599230 (1986-07-01), Milich et al.
patent: 4599231 (1986-07-01), Milich et al.
patent: 4639371 (1987-01-01), Prince et al.
patent: 4649192 (1987-03-01), Van Wijnendaele et al.
patent: 4683136 (1987-07-01), Milich et al.
patent: 4696898 (1987-09-01), Fitts et al.
patent: 4710463 (1987-12-01), Murray
patent: 4722840 (1988-02-01), Valenzuela et al.
patent: 4741901 (1988-05-01), Levinson et al.
patent: 4742158 (1988-05-01), Lehman et al.
patent: 4758507 (1988-07-01), Murray et al.
patent: 4777240 (1988-10-01), Moriarty et al.
patent: 4816564 (1989-03-01), Ellis et al.
patent: 4818527 (1989-04-01), Thornton et al.
patent: 4847080 (1989-07-01), Neurath et al.
patent: 4861588 (1989-08-01), Neurath et al.
patent: 4882145 (1989-11-01), Thornton et al.
patent: 4883865 (1989-11-01), Kubek
patent: 4895800 (1990-01-01), Tschopp et al.
patent: 4935235 (1990-06-01), Rutter et al.
patent: 4942125 (1990-07-01), Moriarty
patent: 4945046 (1990-07-01), Horii et al.
patent: 4959323 (1990-09-01), Acs et al.
patent: 4963483 (1990-10-01), Ellis et al.
patent: 4977092 (1990-12-01), Bitter
patent: 5011915 (1991-04-01), Yamazaki
patent: 5024938 (1991-06-01), Nozaki et al.
patent: 5039522 (1991-08-01), Neurath
patent: 5068185 (1991-11-01), Hopper et al.
patent: 5098704 (1992-03-01), Valenzuela
patent: 5102989 (1992-04-01), Sitrin et al.
patent: 5133961 (1992-07-01), Ellis et al.
patent: 5143726 (1992-09-01), Thornton et al.
patent: 5158769 (1992-10-01), Neurath et al.
patent: 5196194 (1993-03-01), Rutter et al.
patent: 5198348 (1993-03-01), Bitter
patent: 5204096 (1993-04-01), Neurath et al.
patent: 5242812 (1993-09-01), Even-Chen
patent: 5314808 (1994-05-01), Tiollais et al.
patent: 5324513 (1994-06-01), Sobczak et al.
patent: 5436139 (1995-07-01), Rutter et al.
patent: 5462863 (1995-10-01), Hsieh et al.
patent: 5565548 (1996-10-01), Neurath et al.
patent: 5591638 (1997-01-01), Tiollais et al.
patent: 5620844 (1997-04-01), Neurath et al.
patent: 5792463 (1998-08-01), Valenzuela et al.
patent: 5837249 (1998-11-01), Heber-Katz et al.
Alberts et al., Molecular Biology of the Cell, second edition, Garland Publishing Inc., New York and London, pp. 172-173 (1989).
Atassi, "Antigenic Structures of Proteins," Eur. J. Biochem., 145:1-20 (1984).
Atassi et al., "Localization, Synthesis, and Activity of an Antigenic Site on Influenza Virus Hemagglutinin," Proc. Natl. Acad. Sci. USA, 80:840-844 (1983).
Baron et al., "Antibodies Against a Synthetic Peptide of the Poliovirus Replicase Protein: Reaction with Native, Virus-Encoded Proteins and Inhibition of Virus-Specific Polymerase Activities In Vitro," Journal of Virology, 43(3):969-978 (Sep. 1982).
Bittle et al., "Protection Against Foot-and-Mouth Disease by Immunization with a Chemically Synthesized Peptide Predicted from the Viral Nucleotide Sequence," Nature, 298:30-33 (Jul. 1, 1982).
Burrell et al., "Expression in Escherichia coli of Hepatitis B Virus DNA Sequences Cloned in Plasmid pBR322," Nature, 279:43-47 (May 3, 1979).
Dreesman et al., "Antibody to Hepatitis B Surface Antigen after a Single Inoculation of Uncoupled Synthetic HBsAg Peptides," Nature, 295:158-160 (Jan. 14, 1982).
Emtage et al, "The Production of Vaccines by Recombinant DNA Techniques," New Developments With Human and Veterinary Vaccines, pp. 367-409 (1980).
Fritsch et al., "Virology-Cloning the Genome of the Hepatitis B Virus in E. Coli," C.R. Acad. Sci., Paris, 287:1453-1456 (Dec. 18, 1978).
Ganem, "Assembly of Hepadnaviral Virions and Subviral Particles," Current Topics in Microbiology and Immunology, 168:61-83 (1991).
Green et al., "Immunogenic Structure of the Influenza Virus Hemagglutinin," Cell, 28:477-487 (Mar. 1982).
Hemmerling et al., "Comparison of the Entire Pre-S Peptide Sequence to Selected Epitope Sequences in a New Hepatitis B Vaccine Development," International Symposium on Progress in Hepatitis B Immunization (May 3-5, 1989).
Hopp et al., "Prediction of Protein Antigenic Determinants from Amino Acid Sequences," Proc. Natl. Acad. Sci. USA, 78(6):3824-3828 (Jun. 1981).
Landers et al., "Structure of Hepatitis B Dane Particle DNA and Nature of the Endogenous DNA Polymerase Reaction," Journal of Virology, 23(2):368-376 (Aug. 1977).
Lenkei et al., "Receptors for Polymerized Albumin on Liver Cells," Experientia, 33:1046-1047 (1977).
Lerner et al., "Chemically Synthesized Peptides Predicted from the Nucleotide Sequence of the Hepatitis B Virus Genome Elicit Antibodies Reactive with the Native Envelope Protein of Dane Particles," Proc. Natl. Acad. Sci. USA, 78(6):3403-3407 (Jun. 1961).
Machida et al., "A Hepatitis B Surface Antigen Polypeptide (P31) with the Receptor for Polymerized Human as Well as Chimpanzee Albumins," Gastroenterology, 85:268-274 (1983).
Neurath at al., "Antibodies as Immunological Probes for Studying the Denaturation of HBsAg," Journal of Medical Virology, 6:309-322 (1980).
Neurath, "Chemical Synthesis of Hepatitis B Vaccine," Recent Developments in Prophylactic Immunization, vol. 12, Ed. Zuckermann, Kluwer Academic Publishers (1989).
Pasek et al., "Hepatitis B Virus Genes and their Expression in E. Coli," Nature, 282:575-579 (Dec. 6, 1979).
Peterson et al., "Partial Amino Acid Sequence of Two Major Component Polypeptides of Hepatitis B Surface Antigen," Proc. Natl. Acad. Sci. USA, 74(4):1530-1534 (Apr. 1977).
Playfair, "Immune Intervention," New Trends in Vaccines, vol. 1, Ed. I. M. Roitt, Academic Press, London, 1984, pp. 4-7.
Poma et al., "The Superior Immunogenicity of a Pre-S1 Containing HBV Vaccine Compared to a S-Vaccine in Comparative Clinical Trials," Pre-Print of Poster from the 1990 International Symposium on Viral Hepatitis and Liver Disease.
Stibbe et al., "Characterization of Pre-S Gene Products in Hepatitis B Surface Antigen," Developments in Biological Standarization, 54:33-43 (1983).
Stibbe et al., "Structural Relationships Between Minor and Major Proteins of Hepatitis B Surface Antigen," Journal of Virology, 46:626-628 (1983).
Stibbe et al., "Variable Protein Composition of Hepatitis B Surface Antigen from Different Donors," Virology, 123:436-442 (1982).
Thoma et al., "Does the Pre-S2 Have the Same Effect in Improving the HBV Immune Response Compared to Pre-S1?", Pre-Print of Paper Presented at the 1990 International Symposium on Viral Hepatitis and Liver Disease, Apr. 1990 in Houston, Texas.
Thoma et al., "Evaluation of Immune Response in a Third Generation Hepatitis B Vaccine Containing Pre-S Proteins in Comparative Trials," Progress in Hepatitis B Immunization, 194:35-42 (1990).
Thoma et al., "Improvement of the Hepatitis-B Immune Response Through Pre-S Incorporation with Specific Respect to Elderly," Pre-Print of Poster from the 1990 International Symposium on Viral Hepatitis and Liver Disease.
Thoma et al., "Recombinant Hepatitis B Particles Containing Pre-S1 and pre-S2 as a Third Generation Hepatitis B Vaccine," International Conference, Current Trends in Chronically-Evolving Viral Hepatitis, Oct. 5-8, 1988, Fiuggi, Italy.
Thoma et al., "Third Generation Hepatitis B Vaccine Based on Variable Recombinanat Control of Amount of Pre-S, S, and Subtypes Secreted as Particles from Mammalian Cells," Reprint of Presentation from the II International Symposium on Viral Hepatitis and Hepatocellular Carcinoma, Dec. 1988, Taipei, Taiwan.
Tiollais et al, "Biology of Hepatitis B Virus,"
Eisenschenk Chris
Medeva Holdings B.V.
Zeman Mary K
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