Hepatitis B escape mutant specific binding molecules

Details Hepatitis B escape mutant specific binding molecules Hepatitis B escape mutant specific binding molecules

1995-08-28

2000-02-29

Wortman, Donna C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241301, 4241611, 530387, 5303883, 435 5, 435 71, 435 691, 435 7021, 435339, 435346, 435975, C12N 512, A61K 39395, C12Q 170

Patent

active

060306165

ABSTRACT:
Molecules which are capable of specifically binding to a hepatitis B escape mutant antigenic determinant include monoclonal antibodies secreted by the cell line SMH HBs 145/G/R/I (ECACC 92122312). SMH HBs 145/R/I (ECACC 93052626). SMH HBs 145/G/II (ECACC 93033109) or SMH HBs 145/R/II (ECACC 93033110) and other specific binding molecules cross-competitive with them. Antibodies secreted by the cell lines SM HBs 145/G/R/I and SMH HBs 145/G/R/II bind variant (escape mutant) HBsAG and wild type HBsAG. Antibodies secreted by the cell lines SMH HBs 145/R/I and SMH HBs 145/R/II bind variant but not wild type.

REFERENCES:
The Lancet, vol. 336, Aug. 11, 1990, pp. 325-329, Carman et al `Vaccine-induced escape mutant of hepatitis B virus`.
Journal of Medical Virology, vol. 29, 1989, pp. 196-203, Ashton-Rickardt et al, `Mutants of HBsAg that define same antigenically essential residues in the imnmun odominant "a" region`.
Waters et al. 1991 Virus Research vol. 22 p 1-2, Jan. 1, 1991.
Lerner et al. 1981 PNAS USA 78 (6) 3403-3407, Jun. 1, 1981.
Wands et al 1984 PNAS USA 81 2237-2241, Apr. 1, 1984.

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