Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-10-02
1987-01-27
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
424 85, 424 89, 424101, 530387, 530806, 530403, 530415, 530417, 530421, 530380, A61K 3912, A61K 3942, C07K 1504
Patent
active
046393714
ABSTRACT:
There are disclosed a process for enhancing the immunogenicity of a lipid membrane based immunogen comprising flash heating it at a membrane concentrations sufficient under the conditions of flash heating to result in melting of membranes and fusing the melted membranes into novel morphologic forms and a proteinaceous mass comprising particles of HBsAg, said particles including particles of HBsAg in morphologic form not found in nature, said HBsAg contains particles being filaments, branched filaments, closed circular or closed circular branched filaments.
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Brummelhuis et al, Preparation of Hepatitis B Vaccine By Heat-Inactivation, pp. 51-57.
Prince Alfred M.
Vnek John
New York Blood Center Inc.
Schain Howard E.
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