Hepatitis-A viruses adapted to human fibroblast cells

Details Hepatitis-A viruses adapted to human fibroblast cells Hepatitis-A viruses adapted to human fibroblast cells

1990-07-10

1994-06-21

Saunders, David

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

424 89, 4352351, A61K 3929, C12N 708

Patent

active

RE0346446

ABSTRACT:
Hepatitis-A virus, suitable for use in human or animal vaccines, is prepared by adapting the virus first to human kidney cells and subsequently adapting the thus-altered virus to human fibroblast strains. In the process the growth rate of Hepatitis-A virus on the noted tissues is materially increased. This HAV is also a useful antigen in diagnostic test procedures.

REFERENCES:
patent: 4164566 (1979-08-01), Provost et al.
Feinstone, et al., Science vol. 182, pp. 1026-1028, (1973).

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