Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-09-19
1986-11-04
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Lymphokine
514894, 435237, A61K 3929
Patent
active
046209786
ABSTRACT:
Human hepatitis A virus (HAV) can be purified by a process in which master seed lots of HM-175 strain of hepatitis A virus are prepared from triply cloned virus by terminal dilution at passage level about 20 or preferably at least 20-30. The clones tested induced minimal or no hepatitis although significant antibody response was provoked in inoculated primates. A method of preparing the triply cloned inoculum is also described.
REFERENCES:
patent: 4164566 (1979-08-01), Provost et al.
Feinstone, S. M., Daemer, R. J., Gust, I. D., Purcell, R. H., Live Attenuated Vaccine for Hepatitis A, Dev. Biol. Stand. 1983; 54:429-432.
Provost, P. J., Conti, P. A., Giesa, P. A. et al., Studies in Chimpanzees of Live, Attenuated Hepatitis A Vaccine Candidates, Proc. Soc. Exp. Biol. Med. 1983; 172:357-363.
Ticehurst, J. R., Racaniello, V. R., Baroudy, B. M., Baltimore, D., Purcell, R. H., Feinstone, S. M., Molecular Cloning and Characterization of Hepatitis A Virus cDNA, Proc. Natl. Acad. Sci. USA 1983; 80:5885-5889.
von der Helm, K., Winnacker, E. L., Deinhardt, F. et al., Cloning of Hepatitis A Virus Genome, J. Virol. Methods 1981; 3:37-43.
Daemer et al., Infection and Immunity, 32(1):388-393, Apr. 1981.
Purcell et al., "Hepatitis A Virus" (in press).
Daemer Richard J.
Feinstone Stephen M.
Gust Ian D.
Purcell Robert H.
Griffin Ronald W.
Roberts, Jr. John S.
The United States of America as represented by the Department of
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