Hepatitis A virus in a reconstituted influenza virosome and use

Details Hepatitis A virus in a reconstituted influenza virosome and use Hepatitis A virus in a reconstituted influenza virosome and use

1993-03-03

1996-10-15

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242781, 4242811, 4242831, 424450, A61K 3929, A61K 4500, A61K 4744, A61K 9133

Patent

active

055652034

ABSTRACT:
Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) comprising reconstituted functional virus envelopes containing an inactivated hepatitis A virus and an influenza hemagglutinin protein (HA) or a peptide with the amino terminal 21 amino acid residue segment of HA.sub.2 which induces the fusion of the IRIVs with cellular membranes and the lysis of the IRIV. A vaccine containing the hepatitis A IRIVs is also disclosed.

REFERENCES:
patent: 4148876 (1979-04-01), Almeida et al.
patent: 4199565 (1980-04-01), Fullerton et al.
patent: 4663161 (1987-05-01), Mannino et al.
patent: 4731237 (1988-03-01), Reagan et al.
Hughes et al, J. Virol. 55(2):395-401, 1985.
Seganti et al, Microbiologica 12(3) 225-30, 1989 (abstract only included).
Harter et al. J. Biol. Chem. 264(11):6459-6464, 1989.
Mortimer E A, "Diptheria Toxoid" in Vaccines.
Plotkin et al eds. W. B. Saunders Co. 1988 p. 39.
Alving et al, Vaccine 4(3) 166-172, 1986.
Binn et al, J. of Infect. Dis. 153(4):749-756, 1986.
Boslego et al "Gonorrhea Vaccines" in Vaccines and Immunotherapy, S. J. Cryz ed. Pergamon Press, 1991 p. 211-223.
Kallings et al, Lancet I: 955-960, 1988.
Manesis et al, FEBS Letters 102(1):107-111, 1979.
Hackett et al, Immunology 49:255-263, 1983.

Affiliated with

Also associated with

Rating

Hepatitis A virus in a reconstituted influenza virosome and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hepatitis A virus in a reconstituted influenza virosome and use , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis A virus in a reconstituted influenza virosome and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1243958