Hepatitis a virus cell culture in vitro

Details Hepatitis a virus cell culture in vitro Hepatitis a virus cell culture in vitro

1978-08-17

1979-08-14

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

195 13, A61K 3912, C12K 700

Patent

active

041645669

ABSTRACT:
Hepatitis A virus is passaged at least once in a susceptible sub-human primate; the infected liver from such passage is used to inoculate an in vitro cell culture, the inoculated cell culture is incubated until hepatitis A antigen is detected in the cell sheet or culture fluid, and at least two serial in vitro passages in cell culture are carried out. The hepatitis A virus so modified can be used to prepare live, attenuated hepatitis A vaccine or an inactivated hepatitis A vaccine.

REFERENCES:
patent: 3935066 (1976-01-01), Apostolov
patent: 4029764 (1977-06-01), Provost et al.
patent: 4031203 (1977-06-01), Provost et al.
Rightsel et al., Science, vol. 124, (1956), pp. 226-228.
O'Malley et al. - Proc. Exp. Biol. Med., vol. 108, (1961), pp. 200-205.
Liebhaber et al.-J. Exp. Med., vol. 122, (1965), pp. 1135-1150.
O'Malley et al.-Proc. Nat. Acad. Sci., vol. 56, (1965), pp. 895-901.
Mirkovic et al.-Proc. Soc. Exp. Biol. Med., vol. 138, (1971), pp. 626-631.
Dienstag et al.-Intervirology, vol. 6, (1975/1976), pp. 319-324.
Advances in Viral Hepatitis, W.H.O. Technical Report Series, (1977), pp. 15 & 61.

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