Hepatitis A vaccines

Details Hepatitis A vaccines Hepatitis A vaccines

2006-01-31

2006-01-31

Scheiner, Laurie (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S041000, C435S239000

Reexamination Certificate

active

06991929

ABSTRACT:
A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.

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patent: WO 95/17209 (1995-06-01), None
Millman, et al., “Australia Antigen (A Hepatitis-Associated Antigen). Purification and Physical Properties”,Journal of Experimental Medicine, 131(6): 1190-1199, (1970).
André, et al., “Inactivated Candidate Vaccines for Hepatitis A”,Progress in Medical Virology, 37: 72-95, (1990).
Bishop, et al., “Rapid and Efficient Purification of Hepatitis A Virus from Cell Culture”,Journal of Virological Methods, 47(1-2): 203-216, (1994).

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