Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1984-03-02
1986-09-30
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530418, 530806, 530826, C07K 1504
Patent
active
046147934
ABSTRACT:
A surface structural protein of Hepatitis A Virus (HAV) has been isolated and characterized from virus grown in tissue culture. This 33,000 dalton viral protein (VP-1) reacts with immune HAV sera and monoclonal antibodies that neutralize HAV infectivity. The VP-1 is usable for the preparation of a polypeptide subunit vaccine for HAV.
Hybridoma cells were made which produced monoclonal antibodies to HAV or VP-1. These monoclonal antibodies were found to neutralize the infectivity of HAV and to compete with polyclonal antibody derived from human HAV immune sera. The monoclonal antibodies are useful for the neutralization of infectious HAV, the detection of antibodies to neutralizing sites on HAV, and the diagnoses of HAV disease in humans and other susceptible hosts.
REFERENCES:
patent: 4382076 (1983-05-01), Hurni et al.
Journal of Virology (1984), 465-473, vol. 52, No. 2.
Tratschin et al., Journal of Virology, 38:151-156 (1981).
Coulepsis et al., Intervirology, 18:107-127 (1982).
Hughes Joseph V.
Scolnick Edward M.
Tomassini Joanne E.
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
Phillips Delbert R.
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