Hepatic stellate cell specific promoter and uses thereof

Details Hepatic stellate cell specific promoter and uses thereof Hepatic stellate cell specific promoter and uses thereof

2011-01-04

2011-01-04

Schultz, James (Doug) (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S325000, C435S375000, C536S023100, C536S024500

Reexamination Certificate

active

07863251

ABSTRACT:
Methods and reagents for effecting transgene expression in Hepatic Stellate Cells (HSC) comprising a 2.2 kb fragment of the promoter region of the Glial Fibrillary Acidic Protein (GFAP) gene, said construct being up-regulated by pro-fÊbronetic cytokines such as TGF-beta 1 in a dose and time dependent manner, and uses thereof.

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