Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1991-01-18
1997-07-15
Saunders, David
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
435 723, 435 78, 436503, G01N 33566
Patent
active
056482736
ABSTRACT:
The present invention relates to a complex comprising hepatocyte growth factor (HGF) and met proto-oncogene protein. The present invention also relates to methods for detecting the presence of HGF ligand, met proto-oncogene receptor and methods for isolating either the ligand or receptor or complex comprising both. The present invention further relates to methods of diagnostic proliferative disorders and diseases such as hepatitis or hepatocarcinogenesis by detecting these ligand-receptor pairs.
REFERENCES:
patent: 5030565 (1991-07-01), Niman et al.
Miyazawa et al (1989) Biochem Biophys Res Comm 163:967-973.
Nakamura et al (1989) Nature 342:440-443.
Miyazawa et al (1989) "Molecular Cloning & Sequencing ---" Biochem Biophys Res Com 163:967-973.
Giordano et al (1989) "Tyrosine Kinase Receptor ---" Nature 339:155-156.
A. Volver in (E.T. Maggio Ed), Enzyme-Immunoassay, CRC Press Inc., 1980. Chapter 9, pp. 181-196.
Aaronson Stuart A.
Bottaro Donald P.
Chan Andrew M.-L.
Faletto Donna
Rubin Jeffery S.
Saunders David
The United States of America as represented by the Department o
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