Hepatic-directed compounds and reagents for preparation thereof

Details Hepatic-directed compounds and reagents for preparation thereof Hepatic-directed compounds and reagents for preparation thereof

1994-12-07

1999-03-23

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides containing saccharide radicals, e.g., bleomycins, etc.

424 173, 424 9351, 424 943, 514 8, 514 24, 514 54, 514 61, 530345, 530411, 536 176, 536 179, A61K 3814, A61K 5108, C07H 1502, C07K 900

Patent

active

058861432

ABSTRACT:
Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Reagents useful in the preparation of hepatic-directed compounds include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.

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