Hepatic blocking agents

Details Hepatic blocking agents Hepatic blocking agents

1987-05-27

1990-08-07

Draper, Garnette

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, 514 23, 514 59, 514885, 530389, 530391, 435 7, 435810, 436543, A61K 3900

Patent

active

049466755

ABSTRACT:
Novel methods and compositions are provided for the enhancement of the biodistribution of immunoconjugates useful in the diagnosis and treatment of a variety of conditions including cancer in many of its forms. The compositions of the present invention provide for enhanced bioavailability of immunoconjugates for the most part by blocking mammalian cell surface receptors present on cells of the reticuloendothelial system, especially in tissues responsible for the elimination of waste products and blood filtration. Such tissues include the liver, spleen, and kidneys. The compositions are administered in conjunction with an immunoconjugate in a pharmaceutically acceptable vehicle and may be provided in kits for convenient administration.

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