Heparinization of plasma treated surfaces

Details Heparinization of plasma treated surfaces Heparinization of plasma treated surfaces

1985-08-12

1986-09-23

Morgenstern, Norman

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

427 40, 427 41, 424 78, A01N 102

Patent

active

046135170

ABSTRACT:
The disclosure is of a method to improve the antithrombogenicity which results when heparin is attached to a polymeric surface. The polymeric surface is activated by treatment with a plasma. The surface thus activated is rendered receptive to the binding of a surface active agent. The surface active agent in turn reacts with heparin to provide a polymeric surface of exceptional antithrombogenicity when contacted with blood for an extended period of time.

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Gott, Vincent L. et al., Heparin Bonding on Colloidal Graphite Surfaces, Science, vol. 142, pp. 1297-1298, Apr. 25, 1963.
Falb, R. D., Surface-Bonded Heparin, Polymers in Medicine and Surgery, pp. 77-86, Plenum Press, N.Y., 1975.

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